The Panagia Kalyviani Monastery is situated at a height of 80m, approximately 60km south of Heraklion, close to the villages of Mires and Kalyvia. This relatively new monastery was constructed on the remains of an older one.

In 1873, the current church was built on the site of the previous monastery, and the icon of Panagia (Virgin Mary) was discovered in the same year. The Kalyviani complex includes the old church as well as the new temple, which was constructed in 1924 and houses the ancient icon. The new church features three aisles dedicated to the Nativity, the Annunciation, and the Assumption of the Virgin Mary (celebrated on August 15). Additionally, there is a small church dedicated to Saint Haralambos, who was a monk in the monastery and is celebrated on August 23.

Kalyviani exemplifies a foundation that provides assistance and charity to the poor and disadvantaged. In 1956, Bishop Timothy Papoutsakis established a Christian Foundation at the monastery. He constructed an orphanage, hospice, housekeeping school for girls, elementary school, kindergarten, summer camps, and workshops for weaving, knitting, and vestment-making, among other things.